Drug interactions
Avatrombopag + Fluconazole
Severity: Moderate
Avatrombopag and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits both CYP2C9 and CYP3A4, which metabolize avatrombopag, so exposure rises. Increased platelet response may raise the risk of excessive platelet counts and thrombotic events.
What this interaction means in plain words
Avatrombopag and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avatrombopag belongs to Miscellaneous; Fluconazole belongs to Anti Fungals.
Why it happens
Dual inhibition of CYP2C9 and CYP3A4 reduces avatrombopag clearance.
What to do
Use the reduced avatrombopag starting dose recommended in labeling for ITP, and monitor platelet counts and adjust dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Avatrombopag
- Amiodarone + Avatrombopag Moderate
- Amobarbital + Avatrombopag Moderate
- Avatrombopag + Bosentan Moderate
- Avatrombopag + Carbamazepine Moderate
- Avatrombopag + Enzalutamide Moderate
- Avatrombopag + Ketoconazole Moderate
Frequently asked questions
Can I take Avatrombopag with Fluconazole?
MediHelp rates the interaction as moderate. Avatrombopag and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits both CYP2C9 and CYP3A4, which metabolize avatrombopag, so exposure rises. Increased platelet response may raise the risk of excessive platelet counts and thrombotic events.
How serious is the interaction between Avatrombopag and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced avatrombopag starting dose recommended in labeling for ITP, and monitor platelet counts and adjust dose accordingly.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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