Drug interactions
Avatrombopag + Enzalutamide
Severity: Moderate
Avatrombopag and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide induces CYP3A4 and CYP2C9 and can lower avatrombopag exposure, reducing platelet response. This may lead to inadequate platelet counts.
What this interaction means in plain words
Avatrombopag and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avatrombopag belongs to Miscellaneous; Enzalutamide belongs to Endocrine.
Why it happens
Induction of CYP3A4 and CYP2C9 by enzalutamide increases avatrombopag clearance.
What to do
Monitor platelet counts and increase avatrombopag dose per labeling for dual inducers; reassess when enzalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Avatrombopag
- Amiodarone + Avatrombopag Moderate
- Amobarbital + Avatrombopag Moderate
- Avatrombopag + Bosentan Moderate
- Avatrombopag + Carbamazepine Moderate
- Avatrombopag + Fluconazole Moderate
- Avatrombopag + Ketoconazole Moderate
Frequently asked questions
Can I take Avatrombopag with Enzalutamide?
MediHelp rates the interaction as moderate. Avatrombopag and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide induces CYP3A4 and CYP2C9 and can lower avatrombopag exposure, reducing platelet response. This may lead to inadequate platelet counts.
How serious is the interaction between Avatrombopag and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and increase avatrombopag dose per labeling for dual inducers; reassess when enzalutamide is stopped.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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