Drug interactions
Amiodarone + Dolasetron
Severity: Major
Amiodarone and Dolasetron: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolasetron's active metabolite prolongs PR, QRS and QT intervals, and amiodarone is a potent QT-prolonging agent. Together they raise the risk of torsades de pointes and conduction block.
What this interaction means in plain words
Amiodarone and Dolasetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Dolasetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT and conduction interval prolongation by blockade of cardiac ion channels.
What to do
Use an antiemetic with less QT effect, such as a non-QT-prolonging alternative. If unavoidable, obtain a baseline ECG, correct potassium and magnesium, and monitor.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Dolasetron?
MediHelp rates the interaction as major. Amiodarone and Dolasetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dolasetron's active metabolite prolongs PR, QRS and QT intervals, and amiodarone is a potent QT-prolonging agent. Together they raise the risk of torsades de pointes and conduction block.
How serious is the interaction between Amiodarone and Dolasetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an antiemetic with less QT effect, such as a non-QT-prolonging alternative. If unavoidable, obtain a baseline ECG, correct potassium and magnesium, and monitor.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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