Drug interactions
Amiodarone + Duloxetine
Severity: Moderate
Amiodarone and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP2D6 and may increase duloxetine exposure, leading to more nausea, dizziness or blood pressure effects. Both drugs may also have some effect on QT or heart rhythm.
What this interaction means in plain words
Amiodarone and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Duloxetine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6 by amiodarone reduces duloxetine clearance.
What to do
Monitor for duloxetine adverse effects and blood pressure, and reduce the dose if they occur. Check ECG if there are additional QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Amiodarone with Duloxetine?
MediHelp rates the interaction as moderate. Amiodarone and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits CYP2D6 and may increase duloxetine exposure, leading to more nausea, dizziness or blood pressure effects. Both drugs may also have some effect on QT or heart rhythm.
How serious is the interaction between Amiodarone and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects and blood pressure, and reduce the dose if they occur. Check ECG if there are additional QT risk factors.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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