Drug interactions
Amiodarone + Fedratinib
Severity: Moderate
Amiodarone and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is metabolized by CYP3A4 and CYP2C19, and amiodarone inhibits CYP3A4 and may affect CYP2C19, which could raise fedratinib exposure. Higher fedratinib levels increase GI toxicity and risk of encephalopathy.
What this interaction means in plain words
Amiodarone and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Fedratinib belongs to Oncology.
Why it happens
Amiodarone inhibits CYP3A4 (and possibly CYP2C19), reducing fedratinib clearance.
What to do
Monitor for fedratinib toxicity and consider a reduced fedratinib dose per labeling for CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Amiodarone with Fedratinib?
MediHelp rates the interaction as moderate. Amiodarone and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is metabolized by CYP3A4 and CYP2C19, and amiodarone inhibits CYP3A4 and may affect CYP2C19, which could raise fedratinib exposure. Higher fedratinib levels increase GI toxicity and risk of encephalopathy.
How serious is the interaction between Amiodarone and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for fedratinib toxicity and consider a reduced fedratinib dose per labeling for CYP3A4 inhibitors.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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