Drug interactions
Amiodarone + Finerenone
Severity: Moderate
Amiodarone and Finerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may increase finerenone exposure, enhancing its effect on potassium retention. This raises the risk of hyperkalemia and renal function changes.
What this interaction means in plain words
Amiodarone and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Finerenone belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated finerenone metabolism by amiodarone.
What to do
Monitor serum potassium and renal function at initiation and after dose changes. Adjust the finerenone dose or withhold it if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Amiodarone with Finerenone?
MediHelp rates the interaction as moderate. Amiodarone and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may increase finerenone exposure, enhancing its effect on potassium retention. This raises the risk of hyperkalemia and renal function changes.
How serious is the interaction between Amiodarone and Finerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function at initiation and after dose changes. Adjust the finerenone dose or withhold it if potassium rises.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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