Drug interactions
Amiodarone + Hydrochlorothiazide-irbesartan
Severity: Moderate
Amiodarone and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The claimed competition for renal tubular clearance between amiodarone and hydrochlorothiazide is not an established interaction. The relevant concern is that thiazide-induced hypokalemia or hypomagnesemia may increase the risk of QT prolongation and torsades with amiodarone.
What this interaction means in plain words
Amiodarone and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Thiazide-induced hypokalemia and hypomagnesemia add to the QT-prolonging effect of amiodarone.
What to do
Check potassium and magnesium before and during therapy and correct deficits. Monitor the ECG for QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Amiodarone and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The claimed competition for renal tubular clearance between amiodarone and hydrochlorothiazide is not an established interaction. The relevant concern is that thiazide-induced hypokalemia or hypomagnesemia may increase the risk of QT prolongation and torsades with amiodarone.
How serious is the interaction between Amiodarone and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium before and during therapy and correct deficits. Monitor the ECG for QT prolongation.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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