Drug interactions
Amiodarone + Loratadine
Severity: Minor
Amiodarone and Loratadine: minor interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits several CYP enzymes and P-glycoprotein and could modestly raise loratadine levels. Loratadine has a wide safety margin and is not known to cause meaningful QT effects at normal doses, so clinical significance is limited.
What this interaction means in plain words
Amiodarone and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Loratadine belongs to Respiratory.
Why it happens
Inhibition of CYP2D6/CYP3A4 metabolism and P-glycoprotein efflux by amiodarone.
What to do
No dose adjustment is usually necessary. Be aware of additional drowsiness and review ECG monitoring already required for amiodarone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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References
- Amiodarone Hydrochloride - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Loratadine?
MediHelp rates the interaction as minor. Amiodarone and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone inhibits several CYP enzymes and P-glycoprotein and could modestly raise loratadine levels. Loratadine has a wide safety margin and is not known to cause meaningful QT effects at normal doses, so clinical significance is limited.
How serious is the interaction between Amiodarone and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually necessary. Be aware of additional drowsiness and review ECG monitoring already required for amiodarone.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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