Drug interactions
Amiodarone + Oxycodone
Severity: Moderate
Amiodarone and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP3A4 and CYP2D6, which can raise oxycodone exposure and increase sedation and respiratory depression. The CYP2D6 effect may reduce conversion to oxymorphone, though the net effect is mainly higher parent drug.
What this interaction means in plain words
Amiodarone and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Oxycodone belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4 and CYP2D6 by amiodarone reduces oxycodone clearance.
What to do
Monitor for sedation and respiratory depression and reduce the oxycodone dose if needed. Remain vigilant because amiodarone's effect persists after discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Oxycodone?
MediHelp rates the interaction as moderate. Amiodarone and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits CYP3A4 and CYP2D6, which can raise oxycodone exposure and increase sedation and respiratory depression. The CYP2D6 effect may reduce conversion to oxymorphone, though the net effect is mainly higher parent drug.
How serious is the interaction between Amiodarone and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and reduce the oxycodone dose if needed. Remain vigilant because amiodarone's effect persists after discontinuation.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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