Drug interactions
Amiodarone + Ozanimod
Severity: Major
Amiodarone and Ozanimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and delay AV conduction on initiation, and amiodarone has similar effects and prolongs QT. Combined use increases the risk of symptomatic bradycardia, heart block and arrhythmia.
What this interaction means in plain words
Amiodarone and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Ozanimod belongs to Central Nervous System.
Why it happens
Additive negative chronotropic and dromotropic effects with QT prolongation.
What to do
Avoid starting ozanimod in patients on amiodarone unless a cardiologist has reviewed the case. If used, obtain a baseline ECG and monitor heart rate during initiation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Amiodarone with Ozanimod?
MediHelp rates the interaction as major. Amiodarone and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod can slow heart rate and delay AV conduction on initiation, and amiodarone has similar effects and prolongs QT. Combined use increases the risk of symptomatic bradycardia, heart block and arrhythmia.
How serious is the interaction between Amiodarone and Ozanimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting ozanimod in patients on amiodarone unless a cardiologist has reviewed the case. If used, obtain a baseline ECG and monitor heart rate during initiation.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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