Drug interactions
Amiodarone + Palbociclib
Severity: Moderate
Amiodarone and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is metabolized by CYP3A4, and amiodarone is a CYP3A4 inhibitor, which may raise palbociclib levels and neutropenia. Palbociclib may also have a QT effect at higher exposure, adding to amiodarone's risk.
What this interaction means in plain words
Amiodarone and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Palbociclib belongs to Oncology.
Why it happens
CYP3A4 inhibition by amiodarone reduces palbociclib clearance.
What to do
Monitor blood counts and ECG, and reduce the palbociclib dose if neutropenia or QT prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Amiodarone with Palbociclib?
MediHelp rates the interaction as moderate. Amiodarone and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib is metabolized by CYP3A4, and amiodarone is a CYP3A4 inhibitor, which may raise palbociclib levels and neutropenia. Palbociclib may also have a QT effect at higher exposure, adding to amiodarone's risk.
How serious is the interaction between Amiodarone and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and ECG, and reduce the palbociclib dose if neutropenia or QT prolongation develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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