Drug interactions
Amiodarone + Ruxolitinib
Severity: Moderate
Amiodarone and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may increase ruxolitinib concentrations, which could increase myelosuppression such as thrombocytopenia, anemia and neutropenia. The effect is predicted from the mechanism and is likely modest.
What this interaction means in plain words
Amiodarone and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Ruxolitinib belongs to Oncology.
Why it happens
Amiodarone weakly to moderately inhibits CYP3A4, which is the main metabolic pathway of ruxolitinib.
What to do
Monitor complete blood counts more frequently when starting or stopping amiodarone. Adjust the ruxolitinib dose according to labeled hematologic guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Amiodarone with Ruxolitinib?
MediHelp rates the interaction as moderate. Amiodarone and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may increase ruxolitinib concentrations, which could increase myelosuppression such as thrombocytopenia, anemia and neutropenia. The effect is predicted from the mechanism and is likely modest.
How serious is the interaction between Amiodarone and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts more frequently when starting or stopping amiodarone. Adjust the ruxolitinib dose according to labeled hematologic guidance.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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