Drug interactions
Amiodarone + Stiripentol
Severity: Moderate
Amiodarone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces several CYP enzymes including CYP3A4, CYP2C19 and CYP2C8, so amiodarone exposure may shift unpredictably. Either loss of antiarrhythmic effect or toxicity such as bradycardia or QT prolongation could occur.
What this interaction means in plain words
Amiodarone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed inhibition and induction of CYP3A4, CYP2C19 and CYP2C8 by stiripentol altering amiodarone metabolism.
What to do
Monitor ECG, heart rate and arrhythmia control, and adjust amiodarone dose to clinical response when stiripentol is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Amiodarone with Stiripentol?
MediHelp rates the interaction as moderate. Amiodarone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces several CYP enzymes including CYP3A4, CYP2C19 and CYP2C8, so amiodarone exposure may shift unpredictably. Either loss of antiarrhythmic effect or toxicity such as bradycardia or QT prolongation could occur.
How serious is the interaction between Amiodarone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and arrhythmia control, and adjust amiodarone dose to clinical response when stiripentol is started or stopped.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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