Drug interactions
Amiodarone + Tiotropium-olodaterol
Severity: Moderate
Amiodarone and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone markedly prolongs the QT interval, and olodaterol can cause tachycardia and hypokalemia, which raises the risk of ventricular arrhythmias including torsades de pointes. The risk is highest with electrolyte disturbances or structural heart disease.
What this interaction means in plain words
Amiodarone and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta2-agonist-induced hypokalemia and tachycardia.
What to do
Check potassium and magnesium and monitor the ECG and heart rhythm, especially when starting or increasing olodaterol. Keep to the labelled olodaterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Tiotropium-olodaterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tiotropium-olodaterol
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Amiodarone and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone markedly prolongs the QT interval, and olodaterol can cause tachycardia and hypokalemia, which raises the risk of ventricular arrhythmias including torsades de pointes. The risk is highest with electrolyte disturbances or structural heart disease.
How serious is the interaction between Amiodarone and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and monitor the ECG and heart rhythm, especially when starting or increasing olodaterol. Keep to the labelled olodaterol dose.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
