Drug interactions
Dronedarone + Triclabendazole
Severity: Major
Dronedarone and Triclabendazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole can prolong the QT interval, and combined use with dronedarone may increase the risk of torsades de pointes. Risk is higher with electrolyte disturbances or structural heart disease.
What this interaction means in plain words
Dronedarone and Triclabendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive QTc prolongation through effects on cardiac repolarization.
What to do
Avoid if possible; otherwise obtain a baseline ECG, correct potassium and magnesium, and monitor ECG during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Dronedarone with Triclabendazole?
MediHelp rates the interaction as major. Dronedarone and Triclabendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Triclabendazole can prolong the QT interval, and combined use with dronedarone may increase the risk of torsades de pointes. Risk is higher with electrolyte disturbances or structural heart disease.
How serious is the interaction between Dronedarone and Triclabendazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain a baseline ECG, correct potassium and magnesium, and monitor ECG during treatment.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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