Drug interactions
Amisulpride + Clonazepam
Severity: Moderate
Amisulpride and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can increase drowsiness, psychomotor impairment and dizziness. This is especially relevant in elderly or debilitated patients and when doses are being titrated.
What this interaction means in plain words
Amisulpride and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Clonazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation by clonazepam and dopamine antagonism with sedative properties from amisulpride.
What to do
Start with the lowest effective doses and titrate slowly while monitoring sedation and psychomotor function. Advise patients to avoid driving and alcohol until response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Clonazepam?
MediHelp rates the interaction as moderate. Amisulpride and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can increase drowsiness, psychomotor impairment and dizziness. This is especially relevant in elderly or debilitated patients and when doses are being titrated.
How serious is the interaction between Amisulpride and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and titrate slowly while monitoring sedation and psychomotor function. Advise patients to avoid driving and alcohol until response is known.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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