Drug interactions
Amisulpride + Dimenhydrinate
Severity: Moderate
Amisulpride and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate contains diphenhydramine, which is sedating, and it can add to the drowsiness caused by amisulpride. This may impair alertness and coordination.
What this interaction means in plain words
Amisulpride and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Dimenhydrinate belongs to Respiratory.
Why it happens
Additive central nervous system depression through antihistaminic and antipsychotic effects.
What to do
Warn patients about sedation and avoid driving or alcohol. Use the lowest effective dimenhydrinate dose or choose a less sedating antiemetic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Amisulpride with Dimenhydrinate?
MediHelp rates the interaction as moderate. Amisulpride and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate contains diphenhydramine, which is sedating, and it can add to the drowsiness caused by amisulpride. This may impair alertness and coordination.
How serious is the interaction between Amisulpride and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about sedation and avoid driving or alcohol. Use the lowest effective dimenhydrinate dose or choose a less sedating antiemetic.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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