Drug interactions
Amisulpride + Diphenoxylate-atropine
Severity: Moderate
Amisulpride and Diphenoxylate-atropine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both can cause sedation, and combining them may increase drowsiness and impair psychomotor function. Atropine content may also add anticholinergic effects.
What this interaction means in plain words
Amisulpride and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from opioid receptor agonism and antipsychotic dopamine blockade, with some added antimuscarinic effect.
What to do
Monitor for oversedation and anticholinergic effects and counsel on driving; use the lowest effective diphenoxylate dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Diphenoxylate-atropine?
MediHelp rates the interaction as moderate. Amisulpride and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both can cause sedation, and combining them may increase drowsiness and impair psychomotor function. Atropine content may also add anticholinergic effects.
How serious is the interaction between Amisulpride and Diphenoxylate-atropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects and counsel on driving; use the lowest effective diphenoxylate dose.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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