Drug interactions
Amisulpride + Diphenoxylate
Severity: Moderate
Amisulpride and Diphenoxylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid-like antidiarrheal that can cause drowsiness, particularly at higher doses. Combined with amisulpride, sedation and psychomotor impairment may be increased.
What this interaction means in plain words
Amisulpride and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Diphenoxylate belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from opioid receptor agonism and dopamine D2 antagonism.
What to do
Keep diphenoxylate to the lowest effective dose and short duration. Monitor for excessive sedation and counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Amisulpride with Diphenoxylate?
MediHelp rates the interaction as moderate. Amisulpride and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid-like antidiarrheal that can cause drowsiness, particularly at higher doses. Combined with amisulpride, sedation and psychomotor impairment may be increased.
How serious is the interaction between Amisulpride and Diphenoxylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep diphenoxylate to the lowest effective dose and short duration. Monitor for excessive sedation and counsel on driving.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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