Drug interactions
Amisulpride + Lorazepam
Severity: Moderate
Amisulpride and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amisulpride can cause sedation, and with lorazepam the CNS depressant effects are additive. This can cause drowsiness, dizziness and impaired coordination, especially in elderly patients.
What this interaction means in plain words
Amisulpride and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from dopamine antagonism and GABA-A potentiation.
What to do
Start with low doses and monitor for excess sedation, hypotension and falls. Reduce the dose of either drug if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Lorazepam?
MediHelp rates the interaction as moderate. Amisulpride and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amisulpride can cause sedation, and with lorazepam the CNS depressant effects are additive. This can cause drowsiness, dizziness and impaired coordination, especially in elderly patients.
How serious is the interaction between Amisulpride and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor for excess sedation, hypotension and falls. Reduce the dose of either drug if sedation is troublesome.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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