Drug interactions
Amisulpride + Morphine
Severity: Moderate
Amisulpride and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, and using them together can increase sedation, hypotension and respiratory depression. Risk is higher with higher doses, in older adults and in those with respiratory disease.
What this interaction means in plain words
Amisulpride and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and dopamine antagonism with sedative properties.
What to do
Start with the lowest effective doses and monitor sedation, respiratory rate and blood pressure. Reduce the opioid dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Morphine?
MediHelp rates the interaction as moderate. Amisulpride and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, and using them together can increase sedation, hypotension and respiratory depression. Risk is higher with higher doses, in older adults and in those with respiratory disease.
How serious is the interaction between Amisulpride and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and monitor sedation, respiratory rate and blood pressure. Reduce the opioid dose if excessive sedation occurs.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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