Drug interactions
Amisulpride + Nortriptyline
Severity: Major
Amisulpride and Nortriptyline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and amisulpride carries a recognized risk of torsades de pointes. The combination also adds sedation and may raise the risk of arrhythmia in patients with other risk factors.
What this interaction means in plain words
Amisulpride and Nortriptyline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation and additive CNS depression.
What to do
Avoid combining when possible; if needed, check a baseline ECG, correct potassium and magnesium, and monitor the QTc during therapy. Choose alternatives in patients with cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Nortriptyline?
MediHelp rates the interaction as major. Amisulpride and Nortriptyline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and amisulpride carries a recognized risk of torsades de pointes. The combination also adds sedation and may raise the risk of arrhythmia in patients with other risk factors.
How serious is the interaction between Amisulpride and Nortriptyline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when possible; if needed, check a baseline ECG, correct potassium and magnesium, and monitor the QTc during therapy. Choose alternatives in patients with cardiac disease or other QT-prolonging drugs.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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