Drug interactions
Amisulpride + Oxazepam
Severity: Moderate
Amisulpride and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation, and together they can increase drowsiness, dizziness and psychomotor impairment. Elderly or frail patients are at greater risk of falls and over-sedation.
What this interaction means in plain words
Amisulpride and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and dopamine/antipsychotic sedative effects.
What to do
Start with low doses and monitor sedation, especially in older patients; reduce the benzodiazepine dose if excess drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Oxazepam?
MediHelp rates the interaction as moderate. Amisulpride and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation, and together they can increase drowsiness, dizziness and psychomotor impairment. Elderly or frail patients are at greater risk of falls and over-sedation.
How serious is the interaction between Amisulpride and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor sedation, especially in older patients; reduce the benzodiazepine dose if excess drowsiness occurs.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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