Drug interactions
Amisulpride + Primidone
Severity: Moderate
Amisulpride and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital and phenylethylmalonamide, so it carries barbiturate-like sedative effects. With amisulpride, sedation and impaired psychomotor performance may be increased, and antipsychotic-related lowering of seizure threshold may reduce anticonvulsant control.
What this interaction means in plain words
Amisulpride and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Primidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from primidone and its active metabolite phenobarbital with amisulpride.
What to do
Monitor sedation and seizure frequency, and titrate amisulpride gradually. Advise avoidance of alcohol and of driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Amisulpride with Primidone?
MediHelp rates the interaction as moderate. Amisulpride and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolized to phenobarbital and phenylethylmalonamide, so it carries barbiturate-like sedative effects. With amisulpride, sedation and impaired psychomotor performance may be increased, and antipsychotic-related lowering of seizure threshold may reduce anticonvulsant control.
How serious is the interaction between Amisulpride and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and seizure frequency, and titrate amisulpride gradually. Advise avoidance of alcohol and of driving until tolerance is established.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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