Drug interactions
Amisulpride + Salmeterol
Severity: Moderate
Amisulpride and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amisulpride prolongs the QT interval in a dose-dependent manner, and salmeterol can contribute to QT effects and lower potassium. Together they may increase the risk of torsades de pointes, particularly with hypokalemia or cardiac disease.
What this interaction means in plain words
Amisulpride and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Salmeterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2 agonist induced hypokalemia.
What to do
Obtain ECG and electrolytes at baseline in at-risk patients and correct hypokalemia. Monitor QTc and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Salmeterol?
MediHelp rates the interaction as moderate. Amisulpride and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amisulpride prolongs the QT interval in a dose-dependent manner, and salmeterol can contribute to QT effects and lower potassium. Together they may increase the risk of torsades de pointes, particularly with hypokalemia or cardiac disease.
How serious is the interaction between Amisulpride and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG and electrolytes at baseline in at-risk patients and correct hypokalemia. Monitor QTc and use the lowest effective doses.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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