Drug interactions
Amisulpride + Suvorexant
Severity: Moderate
Amisulpride and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Suvorexant is an orexin receptor antagonist hypnotic that causes somnolence and impaired next-day alertness. Combined with amisulpride, CNS depression and psychomotor impairment may be increased.
What this interaction means in plain words
Amisulpride and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression via orexin receptor antagonism and amisulpride's sedative effects.
What to do
Use the lowest effective suvorexant dose and counsel about next-day drowsiness and driving. Reassess the need for both agents if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Amisulpride with Suvorexant?
MediHelp rates the interaction as moderate. Amisulpride and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Suvorexant is an orexin receptor antagonist hypnotic that causes somnolence and impaired next-day alertness. Combined with amisulpride, CNS depression and psychomotor impairment may be increased.
How serious is the interaction between Amisulpride and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective suvorexant dose and counsel about next-day drowsiness and driving. Reassess the need for both agents if impairment occurs.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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