Drug interactions
Amitriptyline + Elagolix
Severity: Minor
Amitriptyline and Elagolix: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix inhibits P-glycoprotein and could modestly raise exposure to amitriptyline. The clinical significance is likely small, though tricyclic adverse effects might be more noticeable.
What this interaction means in plain words
Amitriptyline and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Elagolix belongs to Musculoskeletal.
Why it happens
Elagolix inhibition of intestinal P-glycoprotein efflux may increase amitriptyline absorption.
What to do
No routine dose change is needed; monitor for anticholinergic effects, sedation or palpitations and reduce the amitriptyline dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Amitriptyline with Elagolix?
MediHelp rates the interaction as minor. Amitriptyline and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix inhibits P-glycoprotein and could modestly raise exposure to amitriptyline. The clinical significance is likely small, though tricyclic adverse effects might be more noticeable.
How serious is the interaction between Amitriptyline and Elagolix?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for anticholinergic effects, sedation or palpitations and reduce the amitriptyline dose if they occur.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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