Drug interactions
Amitriptyline + Propofol
Severity: Moderate
Amitriptyline and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline can add to the sedative and hypotensive effects of propofol and may contribute to arrhythmias during anesthesia. The combination may lead to deeper sedation or slower recovery.
What this interaction means in plain words
Amitriptyline and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression and cardiovascular effects, including alpha-blockade and QT effects from the tricyclic.
What to do
Inform the anesthesia team of tricyclic use and titrate propofol to effect with continuous ECG and blood pressure monitoring. Do not stop long-term amitriptyline abruptly without medical advice.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Amitriptyline with Propofol?
MediHelp rates the interaction as moderate. Amitriptyline and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline can add to the sedative and hypotensive effects of propofol and may contribute to arrhythmias during anesthesia. The combination may lead to deeper sedation or slower recovery.
How serious is the interaction between Amitriptyline and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of tricyclic use and titrate propofol to effect with continuous ECG and blood pressure monitoring. Do not stop long-term amitriptyline abruptly without medical advice.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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