Drug interactions
Amitriptyline + Tucatinib
Severity: Minor
Amitriptyline and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-glycoprotein and CYP3A4 and might modestly raise amitriptyline exposure. The clinical effect is uncertain but could include more sedation and anticholinergic effects.
What this interaction means in plain words
Amitriptyline and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits P-glycoprotein and CYP3A4, potentially decreasing efflux and metabolism of amitriptyline.
What to do
No routine dose change is needed; monitor for signs of tricyclic toxicity such as excess sedation or palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Amitriptyline with Tucatinib?
MediHelp rates the interaction as minor. Amitriptyline and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib inhibits P-glycoprotein and CYP3A4 and might modestly raise amitriptyline exposure. The clinical effect is uncertain but could include more sedation and anticholinergic effects.
How serious is the interaction between Amitriptyline and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for signs of tricyclic toxicity such as excess sedation or palpitations.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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