Drug interactions
Amlodipine + Aprepitant
Severity: Minor
Amlodipine and Aprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is metabolised by CYP3A4, and aprepitant is a moderate inhibitor of this enzyme, so amlodipine levels may increase modestly. Effects such as hypotension and peripheral edema could be more pronounced.
What this interaction means in plain words
Amlodipine and Aprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Aprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant inhibits CYP3A4, decreasing amlodipine clearance.
What to do
No routine dose change is needed for a short aprepitant course; monitor blood pressure and edema if used repeatedly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Aprepitant?
MediHelp rates the interaction as minor. Amlodipine and Aprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amlodipine is metabolised by CYP3A4, and aprepitant is a moderate inhibitor of this enzyme, so amlodipine levels may increase modestly. Effects such as hypotension and peripheral edema could be more pronounced.
How serious is the interaction between Amlodipine and Aprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for a short aprepitant course; monitor blood pressure and edema if used repeatedly.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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