Drug interactions
Amlodipine + Armodafinil
Severity: Minor
Amlodipine and Armodafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer and may modestly reduce amlodipine concentrations. This could slightly weaken blood pressure control. Armodafinil may also raise blood pressure on its own.
What this interaction means in plain words
Amlodipine and Armodafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Armodafinil belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 by armodafinil increases amlodipine metabolism.
What to do
Monitor blood pressure after starting or stopping armodafinil. Adjust the amlodipine dose if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Armodafinil
Frequently asked questions
Can I take Amlodipine with Armodafinil?
MediHelp rates the interaction as minor. Amlodipine and Armodafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak CYP3A4 inducer and may modestly reduce amlodipine concentrations. This could slightly weaken blood pressure control. Armodafinil may also raise blood pressure on its own.
How serious is the interaction between Amlodipine and Armodafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping armodafinil. Adjust the amlodipine dose if control is lost.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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