Drug interactions
Amlodipine + Finerenone
Severity: Minor
Amlodipine and Finerenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may modestly raise finerenone exposure. This can increase the risk of hyperkalemia and hypotension, although the effect is usually limited.
What this interaction means in plain words
Amlodipine and Finerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Finerenone belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated finerenone metabolism by amlodipine.
What to do
Check serum potassium and renal function when either drug is started or the dose changed, and adjust finerenone according to potassium results.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Amlodipine with Finerenone?
MediHelp rates the interaction as minor. Amlodipine and Finerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amlodipine is a weak CYP3A4 inhibitor and may modestly raise finerenone exposure. This can increase the risk of hyperkalemia and hypotension, although the effect is usually limited.
How serious is the interaction between Amlodipine and Finerenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function when either drug is started or the dose changed, and adjust finerenone according to potassium results.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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