Drug interactions
Amlodipine + Melatonin
Severity: Minor
Amlodipine and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has been reported to raise blood pressure in patients taking dihydropyridine calcium channel blockers, possibly weakening their antihypertensive effect. The data are limited and the effect is modest in most patients.
What this interaction means in plain words
Amlodipine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Proposed pharmacodynamic antagonism, possibly through melatonin-related vasoconstriction; the mechanism is not firmly established.
What to do
Check blood pressure periodically in hypertensive patients who take melatonin regularly. Adjust antihypertensive therapy only if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Amlodipine with Melatonin?
MediHelp rates the interaction as minor. Amlodipine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has been reported to raise blood pressure in patients taking dihydropyridine calcium channel blockers, possibly weakening their antihypertensive effect. The data are limited and the effect is modest in most patients.
How serious is the interaction between Amlodipine and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure periodically in hypertensive patients who take melatonin regularly. Adjust antihypertensive therapy only if control worsens.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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