Drug interactions
Amlodipine + Ruxolitinib
Severity: Minor
Amlodipine and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and could slightly increase ruxolitinib exposure. This might increase cytopenias or other dose-related effects. A clinically important change is unlikely.
What this interaction means in plain words
Amlodipine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Ruxolitinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by amlodipine slightly reduces ruxolitinib clearance.
What to do
No empirical dose change is needed. Monitor blood counts as usual for ruxolitinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Amlodipine with Ruxolitinib?
MediHelp rates the interaction as minor. Amlodipine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amlodipine is a weak CYP3A4 inhibitor and could slightly increase ruxolitinib exposure. This might increase cytopenias or other dose-related effects. A clinically important change is unlikely.
How serious is the interaction between Amlodipine and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor blood counts as usual for ruxolitinib.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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