Drug interactions
Amlodipine + Temsirolimus
Severity: Moderate
Amlodipine and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of mTOR inhibitors with calcium channel blockers has been associated with a higher incidence of angioedema. Patients should be counseled to report facial, lip or airway swelling promptly.
What this interaction means in plain words
Amlodipine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
The mechanism is not well established; additive effects on bradykinin-related or vascular permeability pathways have been proposed.
What to do
Monitor for angioedema, especially in the first weeks of therapy. Stop the offending drug and treat if swelling occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Amlodipine with Temsirolimus?
MediHelp rates the interaction as moderate. Amlodipine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of mTOR inhibitors with calcium channel blockers has been associated with a higher incidence of angioedema. Patients should be counseled to report facial, lip or airway swelling promptly.
How serious is the interaction between Amlodipine and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for angioedema, especially in the first weeks of therapy. Stop the offending drug and treat if swelling occurs.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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