Drug interactions
Amlodipine-atorvastatin + Chloramphenicol
Severity: Moderate
Amlodipine-atorvastatin and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol inhibits CYP3A4 and may raise amlodipine and atorvastatin concentrations. This could cause hypotension, peripheral edema and a higher risk of statin-related myopathy. Clinical data are limited and the effect is mainly predicted.
What this interaction means in plain words
Amlodipine-atorvastatin and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism by chloramphenicol reduces clearance of amlodipine and atorvastatin.
What to do
Monitor blood pressure and watch for muscle pain or weakness during chloramphenicol therapy. Consider temporarily holding or reducing the atorvastatin dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Amlodipine-atorvastatin with Chloramphenicol?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol inhibits CYP3A4 and may raise amlodipine and atorvastatin concentrations. This could cause hypotension, peripheral edema and a higher risk of statin-related myopathy. Clinical data are limited and the effect is mainly predicted.
How serious is the interaction between Amlodipine-atorvastatin and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and watch for muscle pain or weakness during chloramphenicol therapy. Consider temporarily holding or reducing the atorvastatin dose if symptoms occur.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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