Drug interactions
Amlodipine-atorvastatin + Isavuconazonium
Severity: Moderate
Amlodipine-atorvastatin and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor and raises exposure to amlodipine and atorvastatin, both CYP3A4 substrates. This may cause hypotension, peripheral edema or statin-related muscle toxicity.
What this interaction means in plain words
Amlodipine-atorvastatin and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Isavuconazonium belongs to Anti Fungals.
Why it happens
Isavuconazole inhibits CYP3A4, reducing the metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and edema, and watch for myalgia or weakness. Consider a lower atorvastatin dose if muscle symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Isavuconazonium?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a moderate CYP3A4 inhibitor and raises exposure to amlodipine and atorvastatin, both CYP3A4 substrates. This may cause hypotension, peripheral edema or statin-related muscle toxicity.
How serious is the interaction between Amlodipine-atorvastatin and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and watch for myalgia or weakness. Consider a lower atorvastatin dose if muscle symptoms develop.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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