Drug interactions
Amlodipine-atorvastatin + Lemborexant
Severity: Moderate
Amlodipine-atorvastatin and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine, as a weak CYP3A4 inhibitor, can raise lemborexant levels. This may cause greater next-day somnolence and impaired alertness or driving ability.
What this interaction means in plain words
Amlodipine-atorvastatin and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Lemborexant belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by amlodipine decreases the clearance of lemborexant.
What to do
Limit lemborexant to the reduced maximum nightly dose recommended in labeling for weak CYP3A4 inhibitors. Monitor for daytime sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Lemborexant
Frequently asked questions
Can I take Amlodipine-atorvastatin with Lemborexant?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine, as a weak CYP3A4 inhibitor, can raise lemborexant levels. This may cause greater next-day somnolence and impaired alertness or driving ability.
How serious is the interaction between Amlodipine-atorvastatin and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to the reduced maximum nightly dose recommended in labeling for weak CYP3A4 inhibitors. Monitor for daytime sedation.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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