Drug interactions
Amlodipine-atorvastatin + Lesinurad
Severity: Minor
Amlodipine-atorvastatin and Lesinurad: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lesinurad is a weak CYP3A inducer and may modestly lower amlodipine and atorvastatin exposure. The clinical effect is likely small, but blood pressure and lipid control could be slightly reduced.
What this interaction means in plain words
Amlodipine-atorvastatin and Lesinurad have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-atorvastatin belongs to Cardiovascular; Lesinurad belongs to Genitourinary.
Why it happens
Weak induction of CYP3A4 by lesinurad increases the metabolism of amlodipine and atorvastatin.
What to do
No routine dose change is needed. Check blood pressure and lipid response if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Frequently asked questions
Can I take Amlodipine-atorvastatin with Lesinurad?
MediHelp rates the interaction as minor. Amlodipine-atorvastatin and Lesinurad have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lesinurad is a weak CYP3A inducer and may modestly lower amlodipine and atorvastatin exposure. The clinical effect is likely small, but blood pressure and lipid control could be slightly reduced.
How serious is the interaction between Amlodipine-atorvastatin and Lesinurad?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Check blood pressure and lipid response if control worsens.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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