Drug interactions
Amlodipine-atorvastatin + Mifepristone
Severity: Moderate
Amlodipine-atorvastatin and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may increase amlodipine and atorvastatin exposure. This can enhance hypotension and edema and raise the risk of statin-related myopathy, particularly with chronic higher-dose mifepristone.
What this interaction means in plain words
Amlodipine-atorvastatin and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 by mifepristone reduces the metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and for muscle pain or weakness during mifepristone therapy. Consider limiting the statin dose or choosing a non-CYP3A4 statin if prolonged mifepristone use is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Mifepristone?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase amlodipine and atorvastatin exposure. This can enhance hypotension and edema and raise the risk of statin-related myopathy, particularly with chronic higher-dose mifepristone.
How serious is the interaction between Amlodipine-atorvastatin and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for muscle pain or weakness during mifepristone therapy. Consider limiting the statin dose or choosing a non-CYP3A4 statin if prolonged mifepristone use is needed.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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