Drug interactions
Amlodipine-atorvastatin + Mitotane
Severity: Moderate
Amlodipine-atorvastatin and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and lowers amlodipine and atorvastatin concentrations. This can cause loss of blood pressure and lipid control, and the effect may persist for weeks after mitotane is stopped.
What this interaction means in plain words
Amlodipine-atorvastatin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Mitotane belongs to Oncology.
Why it happens
CYP3A4 induction increases metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and lipid profile and increase doses if needed. Reassess doses after mitotane discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-atorvastatin and Mitotane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-atorvastatin
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Amlodipine-atorvastatin with Mitotane?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and lowers amlodipine and atorvastatin concentrations. This can cause loss of blood pressure and lipid control, and the effect may persist for weeks after mitotane is stopped.
How serious is the interaction between Amlodipine-atorvastatin and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and lipid profile and increase doses if needed. Reassess doses after mitotane discontinuation.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
