Drug interactions
Amlodipine-atorvastatin + Nicardipine
Severity: Moderate
Amlodipine-atorvastatin and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine and nicardipine are both dihydropyridine calcium channel blockers, so combining them duplicates therapy. This increases the risk of hypotension, reflex tachycardia and peripheral edema without added benefit. Nicardipine also inhibits CYP3A4 and may raise amlodipine and atorvastatin levels.
What this interaction means in plain words
Amlodipine-atorvastatin and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Therapeutic duplication with additive calcium channel blockade, plus CYP3A4 inhibition by nicardipine.
What to do
Avoid concurrent use of two dihydropyridines and select a single agent. If overlap occurs, such as during transition from IV nicardipine, monitor blood pressure closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Nicardipine
Frequently asked questions
Can I take Amlodipine-atorvastatin with Nicardipine?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine and nicardipine are both dihydropyridine calcium channel blockers, so combining them duplicates therapy. This increases the risk of hypotension, reflex tachycardia and peripheral edema without added benefit. Nicardipine also inhibits CYP3A4 and may raise amlodipine and atorvastatin levels.
How serious is the interaction between Amlodipine-atorvastatin and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two dihydropyridines and select a single agent. If overlap occurs, such as during transition from IV nicardipine, monitor blood pressure closely.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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