Drug interactions
Amlodipine-atorvastatin + Tinidazole
Severity: Minor
Amlodipine-atorvastatin and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tinidazole is partly metabolised by CYP3A4, and amlodipine is only a weak CYP3A4 inhibitor, so any rise in tinidazole exposure is unlikely to be clinically meaningful. The interaction is largely theoretical.
What this interaction means in plain words
Amlodipine-atorvastatin and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-atorvastatin belongs to Cardiovascular; Tinidazole belongs to Anti Parasitic.
Why it happens
Theoretical weak inhibition of CYP3A4-mediated tinidazole metabolism by amlodipine.
What to do
No dose adjustment is needed; be aware of possible increased tinidazole adverse effects such as gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Amlodipine-atorvastatin with Tinidazole?
MediHelp rates the interaction as minor. Amlodipine-atorvastatin and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tinidazole is partly metabolised by CYP3A4, and amlodipine is only a weak CYP3A4 inhibitor, so any rise in tinidazole exposure is unlikely to be clinically meaningful. The interaction is largely theoretical.
How serious is the interaction between Amlodipine-atorvastatin and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; be aware of possible increased tinidazole adverse effects such as gastrointestinal upset.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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