Drug interactions
Amlodipine-atorvastatin + Verapamil
Severity: Moderate
Amlodipine-atorvastatin and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining amlodipine with verapamil adds two calcium channel blockers, increasing the risk of hypotension, edema, bradycardia and conduction disturbances. Verapamil also inhibits CYP3A4 and may raise amlodipine and atorvastatin concentrations, increasing the risk of statin-related myopathy.
What this interaction means in plain words
Amlodipine-atorvastatin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Additive calcium channel blockade plus CYP3A4 inhibition by verapamil, which reduces metabolism of amlodipine and atorvastatin.
What to do
Avoid routine combination of a dihydropyridine with verapamil unless clearly needed; monitor blood pressure, heart rate and ECG. Watch for muscle pain or weakness and consider a lower atorvastatin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Amlodipine-atorvastatin with Verapamil?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining amlodipine with verapamil adds two calcium channel blockers, increasing the risk of hypotension, edema, bradycardia and conduction disturbances. Verapamil also inhibits CYP3A4 and may raise amlodipine and atorvastatin concentrations, increasing the risk of statin-related myopathy.
How serious is the interaction between Amlodipine-atorvastatin and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination of a dihydropyridine with verapamil unless clearly needed; monitor blood pressure, heart rate and ECG. Watch for muscle pain or weakness and consider a lower atorvastatin dose.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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