Drug interactions
Amlodipine-benazepril + Avanafil
Severity: Moderate
Amlodipine-benazepril and Avanafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil is a PDE5 inhibitor that lowers blood pressure, and it can add to the effect of amlodipine and benazepril. Symptomatic hypotension, dizziness or syncope can occur, especially with several antihypertensives.
What this interaction means in plain words
Amlodipine-benazepril and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Avanafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition and antihypertensive drug effects.
What to do
Start avanafil at the lowest dose and monitor blood pressure and orthostatic symptoms. Counsel the patient to sit or lie down if lightheaded.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Avanafil?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil is a PDE5 inhibitor that lowers blood pressure, and it can add to the effect of amlodipine and benazepril. Symptomatic hypotension, dizziness or syncope can occur, especially with several antihypertensives.
How serious is the interaction between Amlodipine-benazepril and Avanafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start avanafil at the lowest dose and monitor blood pressure and orthostatic symptoms. Counsel the patient to sit or lie down if lightheaded.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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