Drug interactions
Amlodipine-benazepril + Chlorpromazine
Severity: Moderate
Amlodipine-benazepril and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has alpha-blocking properties that cause orthostatic hypotension, which adds to the effect of amlodipine and benazepril. Dizziness and falls may result, especially in older adults.
What this interaction means in plain words
Amlodipine-benazepril and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotension from alpha-1 adrenergic blockade combined with vasodilation and ACE inhibition.
What to do
Monitor blood pressure including standing readings, and counsel patients to rise slowly; reduce doses if orthostasis occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Chlorpromazine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has alpha-blocking properties that cause orthostatic hypotension, which adds to the effect of amlodipine and benazepril. Dizziness and falls may result, especially in older adults.
How serious is the interaction between Amlodipine-benazepril and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including standing readings, and counsel patients to rise slowly; reduce doses if orthostasis occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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