Drug interactions
Amlodipine-benazepril + Lisdexamfetamine
Severity: Moderate
Amlodipine-benazepril and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisdexamfetamine is a sympathomimetic stimulant that can raise blood pressure and heart rate, potentially offsetting the effects of antihypertensive therapy. Blood pressure control may deteriorate.
What this interaction means in plain words
Amlodipine-benazepril and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Amphetamine-induced norepinephrine release causes vasoconstriction and increased cardiac output, opposing antihypertensive effects.
What to do
Monitor blood pressure and heart rate regularly after starting or adjusting the stimulant. Adjust antihypertensive therapy as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lisdexamfetamine is a sympathomimetic stimulant that can raise blood pressure and heart rate, potentially offsetting the effects of antihypertensive therapy. Blood pressure control may deteriorate.
How serious is the interaction between Amlodipine-benazepril and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate regularly after starting or adjusting the stimulant. Adjust antihypertensive therapy as required.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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