Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Apalutamide
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Apalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and can lower amlodipine exposure, reducing its antihypertensive effect. Blood pressure control may be lost.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Apalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Apalutamide belongs to Endocrine.
Why it happens
Apalutamide induces CYP3A4, increasing the metabolism of amlodipine.
What to do
Monitor blood pressure after starting or stopping apalutamide and adjust the antihypertensive regimen as needed. Consider an alternative not metabolized by CYP3A4 if control is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Apalutamide?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Apalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and can lower amlodipine exposure, reducing its antihypertensive effect. Blood pressure control may be lost.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Apalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping apalutamide and adjust the antihypertensive regimen as needed. Consider an alternative not metabolized by CYP3A4 if control is poor.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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