Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Aprepitant
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Aprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and may modestly increase amlodipine exposure, causing more hypotension or edema. The effect is typically limited given the short course of aprepitant therapy.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Aprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Aprepitant belongs to Gastrointestinal Tract.
Why it happens
Moderate, dose-dependent inhibition of CYP3A4 reduces amlodipine metabolism.
What to do
Monitor blood pressure and for dizziness or edema during and shortly after the aprepitant course; adjust amlodipine only if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Aprepitant?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Aprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant is a moderate CYP3A4 inhibitor and may modestly increase amlodipine exposure, causing more hypotension or edema. The effect is typically limited given the short course of aprepitant therapy.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Aprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for dizziness or edema during and shortly after the aprepitant course; adjust amlodipine only if symptoms occur.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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