Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Armodafinil
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Armodafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer and may slightly lower amlodipine concentrations. Armodafinil can also raise blood pressure, which could work against antihypertensive therapy.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Armodafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Armodafinil belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 increases amlodipine clearance; armodafinil may also have a pressor effect.
What to do
Monitor blood pressure after starting or stopping armodafinil and adjust antihypertensive therapy if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Armodafinil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Armodafinil
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Armodafinil?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Armodafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak CYP3A4 inducer and may slightly lower amlodipine concentrations. Armodafinil can also raise blood pressure, which could work against antihypertensive therapy.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Armodafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping armodafinil and adjust antihypertensive therapy if control changes.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
